The effects of mycotoxin risk on poultry management

Effects of mycotoxins on poultry gut health 


  • The disruption of intestinal barrier function  
  • Poor intestinal cell proliferation and cell death 
  • Compromised intestinal immunity. 
  • Altered intestinal nutrient absorption. 
  • Increased intestinal permeability.
  • Intestinal cell death 
  • Decreased villi height. 
T-2 toxin / DON 
  • Poor intestinal water and glucose absorption (diarrhea) 
  • Necrotic lesions in GIT 
  • Shortening of intestinal villi (poor nutrient absorption) 
  • Increased intestinal permeability (lowered tight junction proteins) 
  • Decreased IL-8* cytokine (responsible for pathogen removal) 
  • Decreased mucin production. 
  • Decreased cell viability and proliferation. 
  • Altered intestinal barrier integrity by suppressing tight junction protein. 
  • Increased intestinal permeability. 
  • Increased mucin secretion/depletion of goblet cells 
  • Altered gut immunity.  

Effects of mycotoxins on poultry immune system 



Increased gene expression of IL-6*, reduced complement and interferon, suppressed macrophagic phagocytosis, suppressed DTH, reduced weight of thymus and bursa, poor antibody titers, vaccination failures. 


Regression of lymphoid organs, lymphocyte depletion, poor DTH*, and antibody response is affected to a lesser extent. 

T-2 toxin 

Regression of bursa of Farbricius, leucopenia, proteinemia, immunosuppression, increased disease incidences 


Interferes with DNA, RNA and protein synthesis, immunosuppression, poor antibody titers, increased disease incidences. 

  • Thymus atrophy, decreased spleen weight, increased susceptibility to E. coli and other bacteria. 
  •  Interleukin-6, DHT - Delayed-type hypersensitivity 



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